TargetMol—Star Molecules—MRTX1133 (Cat. No. T9303, CAS. 2621928-55-8), Potent Inhibition of the KRASG12D Mutant via a non-Covalent Binding Strategy
1. Product Introduction MRTX1133 (Cat. No. T9303, CAS. 2621928-55-8), is a KRASG12D inhibitor (KD = 0.2 pM) with high potency, selectivity, and non-covalent binding. MRTX1133 exhibits inhibitory activity against tumors harboring the KRASG12D mutation, while it shows no inhibitory activity against KRAS wild-type tumors. Molecular structure of MRTX1133 2. Background Introduction KRAS is an important [...]