TargetMol Star Molecule—Resatorvid (TQ0181, CAS 243984-11-4), a tool compound for research on sepsis, neuroinflammation, and aseptic inflammation
Resatorvid, catalog number TQ0181, CAS number 243984-11-4, also known as CLI-095 and TAK-242. Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 in the intracellular TIR domain of TLR4, preventing TLR4 from binding to TIRAP and thereby blocking downstream signal transduction. Resatorvid exhibits [...]