1,2-Hexanediol (CAS No.: 6920-22-5) has become an indispensable ingredient in today' s cosmetic formulations due to its multifunctional performance and excellent safety profile. As a colorless, transparent liquid with the molecular formula C6H14O2 and a molecular weight of 118.17, this diol offers strong water solubility, a mild scent, and hygroscopic properties. Beyond its physical characteristics—such as a boiling point of 223–224°C, melting point of -40°C, density of 0.951 g/mL at 25°C, and broad solubility in water, ethanol, chloroform, ethers, and methanol—its value in skincare lies in its unique combination of moisturizing, antimicrobial, and formulation-supporting functions. In this blog post, SACH will share what makes 1 2-hexanediol an essential ingredient for skin benefits in cosmetics, highlighting its unique moisturizing and antibacterial properties.

How 1,2-Hexanediol Benefits for Skin Through Moisture Retention

One of the most notable 1,2-hexanediol benefits for skin is its strong humectant ability. As a multifunctional diol, it attracts and binds water within the stratum corneum, helping maintain skin softness and flexibility. Its hygroscopic nature allows it to interact with moisture in the environment, contributing to longer-lasting hydration without leaving a greasy or heavy residue.

Unlike traditional moisturizers that rely solely on occlusive barriers, 1,2-hexanediol improves the skin' s water balance from within. This is particularly valuable in lightweight formulations such as serums, toners, and lotions where non-sticky hydration is required. Its stable chemical structure and mild pKa value (14.49±0.20) ensure it remains effective across a range of pH environments commonly used in skincare.

Antimicrobial Effects: Another Core 1,2-Hexanediol Benefit for Skin Health

Beyond hydration, 1,2-hexanediol (CAS No.: 6920-22-5) supports skin health by offering consistent antimicrobial performance. It demonstrates broad-spectrum antibacterial and antifungal activity by disrupting microbial cell membranes. This mechanism reduces the need for traditional preservatives such as parabens or formaldehyde donors.

Its mild yet effective antimicrobial action makes it ideal for:

* Sensitive-skin formulations

* "Preservative-free" or "low preservative" product concepts

* Clean beauty lines demanding gentle ingredient systems

By inhibiting microbial proliferation, 1,2-hexanediol helps maintain product integrity while minimizing irritation risks. This dual functionality—hydration plus antimicrobial defense—is a major reason it is favored in modern cosmetic science.

Role of 1,2-Hexanediol in Skin Conditioning and Sensory Improvement

While often discussed for its preservation and humectant qualities, 1,2-hexanediol also contributes to overall skin conditioning. As a diol, it interacts favorably with both hydrophilic and hydrophobic components, improving product spreadability and skin feel.

Key benefits include:

* Softer, smoother application

* Enhanced absorption of active ingredients

* Reduced tackiness in high-glycerin formulations

* Balanced viscosity and improved formula stability

These advantages make it a versatile ingredient not only for skincare but also for sunscreens, body washes, and shampoos, where sensory performance is essential.

Why Formulators Value 1,2-Hexanediol in Cosmetic Preservation Systems

Among all 1,2-Hexanediol benefits for skin, its role in reducing preservative load is among the most important for formulators. As consumer demand shifts toward low-irritation and "minimalist" formulations, this multifunctional diol helps bridge the gap between safety and product performance.

Synergistic Preservation Capabilities

1,2-Hexanediol works exceptionally well in combination with:

* Organic acids (such as benzoic acid derivatives)

* Other polyols (e.g., pentylene glycol, butylene glycol)

* Mild preservatives in natural formulations

These synergistic interactions enhance microbial control while maintaining mildness, stability, and cosmetic elegance.

Enabling Additive-Free Concepts

Because it can perform as a humectant, skin conditioner, solvent, and antimicrobial booster, 1,2-hexanediol simplifies formulation design. This is especially important for:

* Sensitive-skin product lines

* Baby care formulations

* "No traditional preservatives" marketing claims

Broad Applications Showing the Benefits of 1,2-Hexanediol for Skin

Thanks to its functional features and high compatibility with surfactants, thickeners, and active ingredients, 1,2-hexanediol appears in a wide range of personal care categories:

* Facial creams and emulsions

* Hydrating serums and gel-based cosmetics

* Sunscreens and after-sun products

* Cleansers, body washes, and shampoos

* Scalp-care and hair-repair treatments

* Toners, essence waters, and micellar formulations

Its ability to dissolve various raw materials and stabilize complex systems further expands its usage across modern cosmetic manufacturing.

Final Thoughts

The diverse 1,2-Hexanediol benefits for skin—from moisture retention and microbial protection to formulation support—demonstrate why this diol has become a cornerstone of today' s cosmetic industry. Its high purity, global regulatory compliance, excellent compatibility, and multifunctional properties offer strong value to manufacturers while providing gentle, effective performance for end users.

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